This book highlights the first systematic synthesis of various research approaches in forensic medical diagnosis of the morphological and polycrystalline structure of human biological tissues and biological fluids. One of the global challenges in such diagnosis is the assessment of actual time of death. The relevance and objectivity of such studies are given by the innovative use of complex multifunctional methods using lasers and Mueller-matrix polarimetry, which is presented in this book. As a result, within the framework of the statistical, correlation and fractal approaches, diagnostic relationships were established between the time parameters of the transformation of the topographic structure of polarization-inhomogeneous microscopic images of biological preparations and necrotic changes in the morphological structure of biological tissues of the deceased. On this foundation, new forensic medicine criteria have been developed for objective determination of time of death.